Mutant cartoon movie

Never saw the movie but I have seen its trailer dozens of times back in the 2000’s.

It was a 2-D animated movie. An evil scientist guy with an apple core head (probably a once human-turned-mutant) creates a formula that mutates animals into monsters and it’s up to some kids (probably) teens to stop him while facing the monsters including a mutated frog. At one point, the villain has somehow grown to giant-size too.

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